Man can be made spiritually whole living in God.
But of him are ye in Christ Jesus, who of God is made unto us wisdom, and righteousness, and sanctification, and redemption: That, according as it is written, He that glorieth, let him glory in the Lord. (1 Corinthians 1:30-31 KJV)
There is no wisdom, righteousness, sanctification, or redemption found in anything of this world. These four spiritual things are central to living a successful Christian life and can only be found in personally possessing the essence of God. The world has nothing godly or eternal to offer mankind. Man in his natural state is full of evil and darkness following after the god of this world dwelling far removed from the supernatural light and righteousness of God.
Without godly knowledge there is no wisdom but only vain philosophy and twisted thinking of natural mankind. There is nothing righteous in this world apart from having the holiness and righteousness of God.
Sanctification is a supernatural function of The Holy Spirit which is the spirit of God living within the quickened man nothing else can cleanse and sanitize mankind’s heart and mind removing his natural sin ridden state other than the presence of God.
Redemption is a finished work of Jesus Christ through His shed blood and only He could offer the perfect sacrifice that would atone for all sin of mankind paying the ledger in full.